Esketamine / Spravato in Las Vegas
SPRAVATO™ for treatment-resistant depression
An FDA-approved esketamine nasal spray, given in the comfort of our Las Vegas office under the supervision of our psychiatric team. For many people, it’s the first thing in years that feels different.
- FDA-approved
- Medicare & most major plans
- We help with prior authorization
What is SPRAVATO™?
SPRAVATO™, or esketamine, is an innovative FDA-approved treatment that has relieved thousands of individuals suffering from treatment-resistant depression. Administered as a nasal spray under the supervision of a certified healthcare provider, SPRAVATO™ is unique in that it may be able to alleviate symptoms of depression faster than the weeks or months a typical antidepressant may take.
SPRAVATO™ is an esketamine nasal spray that is used in combination with an oral antidepressant. SPRAVATO™ can alleviate the symptoms of treatment-resistant depression and Major Depressive Disorder (MDD).
Spravato isn’t like other antidepressant treatments. Standard antidepressant medications boost levels of naturally formed chemicals in the brain like dopamine, norepinephrine, and serotonin. These neurotransmitters are the chemical messengers of the brain, key to initiating and regulating how cells communicate. When these chemical messengers are weakened or damaged, it’s difficult to control moods, which is a symptom of many kinds of mental illness. SPRAVATO™ works on a different system: glutamate, the brain’s most abundant chemical messenger. That is part of why it can help people who haven’t responded to other medications.
If you’re struggling with treatment-resistant depression, contact Calm Clinic today to find out how Spravato can help you. For more information please visit spravato.com.
You may be a candidate if you…
- Are an adult diagnosed with major depressive disorder
- Have tried at least two antidepressants without enough relief
- Are still struggling with low mood, hopelessness, or loss of interest
- Want an option that works differently from daily pills
Only a provider can determine if SPRAVATO™ is right for you. We start every patient with a comprehensive evaluation.
See if I qualify2-minute check
See if SPRAVATO™ may be right for you
Answer a few quick questions. If it looks like a fit, you can book a consult with Dr. Grant Bullock right away.
Your answers stay on your device. We don’t save or send them. This isn’t a diagnosis; your provider makes the final call at your consult.
Booking opens our Calm Clinic scheduling page. In-office treatment in Las Vegas, Nevada patients only.
SPRAVATO™ treatment at Calm Clinic
Calm Clinic offers SPRAVATO™ to help you alleviate your depression symptoms and restore your quality of life. Here’s what to expect.
Evaluation
Prior to beginning treatment, our office will conduct a comprehensive evaluation to determine if SPRAVATO™ is the best option for you.
Treatment day
SPRAVATO™ is prescribed in one of two dosages: 56mg or 84mg. During treatment, you will rest comfortably under the supervision of a certified SPRAVATO™ specialist for approximately 2 hours.
Heading home
SPRAVATO™ can trigger some short-lived side effects such as dizziness, dissociation, and sedation. These side effects usually happen right after taking SPRAVATO™ and go away the same day. Once the provider has released you, you will need a friend or family member to drive you home.
Standard SPRAVATO™ Treatment Plan
- Month 1 · Weeks 1–4Two treatments per week
- Month 2 · Weeks 5–8One treatment per week
- Month 3 and beyondContinue weekly treatment or treatment once every 2 weeks
Your provider will tailor the schedule to how you respond.
Why Calm Clinic
Your psychiatrist and your SPRAVATO™ team, under one roof
Many SPRAVATO™ centers only administer the medication. At Calm Clinic, the same local psychiatric team manages your medications, therapy, and treatment, so nothing falls through the cracks.
- Psychiatrist-led care, trained at Johns Hopkins and UNLV
- In network with Medicare, Medicaid and most major plans
- Talk therapy available alongside treatment
- TMS and ketamine therapy available if SPRAVATO™ isn’t the right fit
“I’ve never had my psychiatrist and therapist work so closely in my care. I’ve been through a lot, and I knew medications helped, but I was finally able to be happy again.”
Talk to us about SPRAVATO™
To speak with a representative about your options, call our office or request an appointment online and a representative will reach out to you.
Frequently Asked Questions
What is treatment resistant depression?
In the SPRAVATO™ clinical trials, treatment-resistant depression was diagnosed in adults who were struggling with major depressive disorder and had not responded adequately to at least two different antidepressants of adequate dose and duration in the current depressive episode.
How is Spravato nasal spray different than ketamine infusion?
SPRAVATO™ (esketamine) CIII nasal spray is a derivative of ketamine. SPRAVATO™ is an FDA-approved nasal spray for treatment-resistant depression; it is also approved to treat depressive symptoms in adults with major depressive disorder with suicidal thoughts or actions. Ketamine has not been approved by the FDA to treat depression. Both SPRAVATO™ and ketamine are Schedule III controlled substances under the US Controlled Substances Act. Calm Clinic also offers ketamine assisted psychotherapy.
Is SPRAVATO™ covered by insurance?
SPRAVATO™ is covered by many commercial insurance plans as well as Medicare and Medicaid for patients who qualify. Most plans require a prior authorization. Our team will check your benefits and walk you through what to expect before your first treatment. See the insurance plans we accept.
How quickly might I see improvements in depressive symptoms with Spravato for treatment-resistant depression?
In clinical studies, improvement of depressive symptoms was demonstrated at four weeks by SPRAVATO™ plus an oral antidepressant, compared with placebo nasal spray plus an oral antidepressant. Not all patients will respond to SPRAVATO™.
Can I drive myself home after treatment?
No. After each session you will rest in our office for about two hours while we monitor you. Once your provider has released you, you will need a friend, family member, or rideshare to take you home. Do not drive or operate machinery until the next day after a restful sleep.
What personal items can I bring to my treatment session?
You can bring personal items that make you feel comfortable which may include headphones, a music player, a tablet, crossword puzzles or a book to pass the time, and a blanket and pillow to help you relax.
What happens during the observation period after taking SPRAVATO™?
The observation period begins right after the treatment is administered. During this time patients will be allowed to rest comfortably and will be monitored by a healthcare provider for any side effects you may experience. You should expect your healthcare provider to ask you about the side effects and have your blood pressure taken periodically during the observation period.
What side effects could I experience on SPRAVATO™?
The most common side effects include feeling disconnected from yourself, your thoughts, feelings, and things around you (dissociation); dizziness; nausea; feeling sleepy (sedation); spinning sensation; decreased feeling of sensitivity (numbness); feeling anxious; lack of energy; increased blood pressure; vomiting; feeling drunk; and feeling very happy or excited. These side effects usually happen right after taking SPRAVATO™ and go away the same day.
Other possible serious side effects include increased blood pressure, problems with thinking clearly, and bladder problems. Serious side effects reported with SPRAVATO™ include sedation and dissociation, and there is a risk of abuse and misuse. There is an increased risk of suicidal thoughts and behavior. Call your healthcare provider right away if you have new or sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or behavior.
Because of the possibility of nausea and vomiting, you should avoid eating two hours before, and drinking liquids 30 minutes before, taking SPRAVATO™.
What should I tell my healthcare provider before starting Spravato?
Before starting, tell your healthcare provider about your full medication and depression treatment history, including if you have a history abusing prescription or street drugs, or a problem with alcohol. Do not take SPRAVATO™ if you have: a blood vessel disease (aneurysm), an abnormal connection between your blood vessels (arteriovenous malformation), a history of bleeding in the brain or if you are allergic to esketamine, ketamine or any of the ingredients in SPRAVATO™.
Be sure to tell your healthcare provider if you have heart, brain or liver problems; if you have psychosis; or if you are pregnant, planning to become pregnant, breastfeeding or planning to breastfeed. You should not take SPRAVATO™ if you are pregnant. You should not breastfeed if you are taking SPRAVATO™.
Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.
For more FAQ’s about SPRAVATO™, please visit: spravato.com/trd/faqs.
What if SPRAVATO™ isn’t right for me?
You still have options. Calm Clinic also offers TMS therapy, which is non-invasive and medication-free, and ketamine assisted psychotherapy. Compare your options.
Important safety information
SPRAVATO™ can cause sedation, dissociation, respiratory depression, and has a risk of abuse and misuse. Because of these risks, it is only available through a restricted program and must be taken under the supervision of a healthcare provider in a certified setting, with monitoring for at least 2 hours afterward. Antidepressants may increase the risk of suicidal thoughts and behaviors in some people, especially those 24 years of age and younger. SPRAVATO™ is not for use in children.
This page is for educational purposes and does not replace the full Prescribing Information and Medication Guide. See the full safety information at spravato.com and talk with your provider. For more FAQs, visit spravato.com/trd/faqs.